Article
Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium.
Protein science : a publication of the Protein Society - 1 Dec 1998
Cai M, Huang Y, Caffrey M, Zheng R, Craigie R, Clore G M, Gronenborn A M
Abstract excerpt
The solution structure of His12 --> Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild-type N-terminal doma...
Topics
- Binding Sites
- Cadmium
- Cysteine
- HIV Integrase
- Histidine
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Mutation
- Protein Conformation
- Zinc