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Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2007

Xu Wang-Hong, Shrubsole Martha J, Xiang Yong-Bing, Cai Qiuyin, Zhao Gen-ming, Ruan Zhi-xian, Cheng Jia-rong, Zheng Wei, Shu Xiao Ou

Abstract excerpt

Folate plays an important role in carcinogenesis. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), encoded by the MTHFR gene, is involved in this process. We investigated both the independent and joint effects of dietary folate and other methyl-related nutrients, as well as three polymorphisms of MTHFR (677C>T, 1298A>C, and 1793G>A), on endometrial cancer risk in a population-based case-control study....

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PMID: 17301261
DOI: 10.1158/1055-9965.EPI-06-0798

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MTHFR

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