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Article

Two novel imatinib‐responsive <i>PDGFRA</i> fusion genes in chronic eosinophilic leukaemia

6 Jun 2007

Abstract excerpt

We identified two patients with a t(2;4)(p24;q12) and a t(4;12)(q2?3;p1?2), respectively, in association with BCR-ABL and FIP1L1-PDGFRA negative chronic eosinophilic leukaemia. Molecular analysis revealed a novel STRN-PDGFRA fusion for the t(2;4) and ETV6-PDGFRA for the t(4;12). The fusions were confirmed by specific amplification of the genomic breakpoints, reverse transcription polymerase chain reaction and...

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Share to Chronic Myeloid Leukemia Treatments
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Identifiers

PMID: 17555450
DOI: 10.1111/j.1365-2141.2007.06628.x

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