Article
Cardiac stem cells in brown adipose tissue express CD133 and induce bone marrow nonhematopoietic cells to differentiate into cardiomyocytes.
Stem cells (Dayton, Ohio) - 1 May 2007
Yamada Yoshihiro, Yokoyama Shin-ichiro, Wang Xiang-Di, Fukuda Noboru, Takakura Nobuyuki
Abstract excerpt
Recently, there has been noteworthy progress in the field of cardiac regeneration therapy. We previously reported that brown adipose tissue (BAT) contained cardiac progenitor cells that were relevant to the regeneration of damaged myocardium. In this study, we found that CD133-positive, but not c-Kit- or Sca-1-positive, cells in BAT differentiated into cardiomyocytes (CMs) with a high frequency. Moreover, we...
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