Article
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
JAMA - 7 Feb 2007
Smith Nicholas L, Hindorff Lucia A, Heckbert Susan R, Lemaitre Rozenn N, Marciante Kristin D, Rice Kenneth, Lumley Thomas, Bis Joshua C, Wiggins Kerri L, Rosendaal Frits R, Psaty Bruce M
Abstract excerpt
CONTEXT: Although the roles of clotting proteins and enzymes that activate or inhibit fibrin production and lysis are well characterized, the underlying contribution of genetic variation in these constituents to risk of venous thrombosis (VT) has not been fully investigated. OBJECTIVE: To describe the association of common genetic variation in 24 coagulation, anticoagulation, fibrinolysis, and antifibrinolysis...
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