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Article

Identification of a unique epigenetic sub‐microenvironment in prostate cancer

2 Feb 2007

Abstract excerpt

The glutathione S-transferase P1 (GSTP1) gene promoter is methylated in tumour cells in more than 90% of prostate carcinomas. Recently, GSTP1 promoter methylation was identified in tumour-associated stromal cells in addition to the tumour epithelium. To define the extent and location of stromal methylation, epigenetic mapping using pyrosequencing quantification of GSTP1 promoter methylation and an anatomical...

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PMID: 17278115
DOI: 10.1002/path.2133

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