Article
Retroviral microarray-based platform on nanostructured TiO2 for functional genomics and drug discovery.
Biomaterials - 1 Apr 2007
Carbone Roberta, Giorgetti Luca, Zanardi Andrea, Marangi Ida, Chierici Elisabetta, Bongiorno Gero, Fiorentini Francesca, Faretta Mario, Piseri Paolo, Pelicci Pier Giuseppe, Milani Paolo
Abstract excerpt
Living-cell microarrays are powerful tools for functional genomics and drug discovery. However, despite several attempts to improve this technology, it is still a challenge to obtain microarrays of cells efficiently overexpressing or downregulating specific genes to address complex phenotypes. Here, we present a cell-based microarray for phenotype screening on primary and cancer cells based on the localized...
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