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Article

Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity

30 Jan 2007

Abstract excerpt

NO, the product of endothelial NOS (eNOS), is a major regulator of vascular homeostasis and a critical factor in preventing cardiovascular diseases. We previously established a positive correlation between the number of variable CA repeats in intron 13 of human eNOS and the risk of coronary artery disease, and demonstrated that these polymorphic CA repeats function as a length-dependent splicing enhancer. By...

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Share to Nitric Oxide and Endothelin Effects
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PMID: 17264164
DOI: 10.1096/fj.06-7434com

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