Article
Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2007
Zhang Jian Gang, Eguchi Junichi, Kruse Carol A, Gomez German G, Fakhrai Habib, Schroter Stephanie, Ma Wenxue, Hoa Neil, Minev Boris, Delgado Christina, Wepsic H Terry, Okada Hideho, Jadus Martin R
Abstract excerpt
PURPOSE: Allogeneic glioma cell lines that are partially matched to the patient at class I human leukocyte antigen (HLA) loci and that display tumor-associated antigens (TAA) or antigenic precursors [tumor antigen precursor proteins (TAPP)] could be used for generating whole tumor cell vaccines or, alternatively, for extraction of TAA peptides to make autologous dendritic cell vaccines. EXPERIMENTAL DESIGN:...
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