Article
Selection of a gyrA mutation and treatment failure with gatifloxacin in a patient with Streptococcus pneumoniae with a preexisting parC mutation.
Pharmacotherapy - 1 Feb 2007
Kays Michael B, Zhanel George G, Reimann Megan A, Jacobi Judi, Denys Gerald A, Smith David W, Wack Matthew F
Abstract excerpt
An 81-year-old woman had pneumonia caused by Streptococcus pneumoniae (levofloxacin Etest minimum inhibitory concentration [MIC] 1.5 microg/ml) and was treated with intravenous gatifloxacin 200 mg/day. After 3 days of therapy, repeat sputum cultures were positive for S. pneumoniae, which was resi...
Topics
- Aged, 80 and over
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance
- Female
- Fluoroquinolones
- Gatifloxacin
- Humans
- Mutation
- Pneumococcal Infections
- Streptococcus pneumoniae
- Treatment Failure