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Article

The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function.

Nucleic acids research - 1 Jan 2007

Farge Géraldine, Pham Xuan Hoi, Holmlund Teresa, Khorostov Ivan, Falkenberg Maria

Abstract excerpt

The mitochondrial replication machinery in human cells includes the DNA polymerase gamma holoenzyme and the TWINKLE helicase. Together, these two factors form a processive replication machinery, a replisome, which can use duplex DNA as template to synthesize long stretches of single-stranded DNA. We here address the importance of the smaller, accessory B subunit of DNA polymerase gamma and demonstrate that this...

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Identifiers

PMID: 17251196
DOI: 10.1093/nar/gkl1116
PMCID: PMC1807957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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