Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2007

Salisbury Travis B, Binder April K, Grammer Jean C, Nilson John H

Abstract excerpt

GnRH regulates expression of LHB via transcriptional regulation of early growth response 1 (EGR1), an immediate early gene that encodes a zinc-finger DNA-binding protein. EGR1 interacts functionally with the orphan nuclear receptor steroidogenic factor 1 (SF1) and pituitary homeobox 1, a member of the paired-like homeodomain family. The functional synergism of this tripartite interaction defines the maximal level...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Early Growth Response Protein 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gonadotropin-Releasing Hormone

Share to Immunoprecipitation

Share to Paired Box Transcription Factors

Share to Receptors, Cytoplasmic and Nuclear

Share to RNA, Small Interfering

Share to Steroidogenic Factor 1

Source

Identifiers

PMID: 17244763
DOI: 10.1210/me.2006-0383

Genes

EGR1
LHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.PMID 17244763Read ↗

Welcoming β-Catenin to the Gonadotropin-Releasing Hormone Transcriptional Network in GonadotropesSemantic proximity Read ↗

Conservation of mechanisms mediating gonadotrophin-releasing hormone 1 stimulation of human luteinizing hormone β subunit transcriptionSemantic proximity Read ↗

Activation of Luteinizing Hormone β Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1Semantic proximity Read ↗

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.Semantic proximity Read ↗

Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHBSemantic proximity Read ↗

Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1.Semantic proximity Read ↗

Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression.Semantic proximity Read ↗

A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice.Semantic proximity Read ↗

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.Semantic proximity Read ↗

Activator Protein-1 and Smad Proteins Synergistically Regulate Human Follicle-Stimulating Hormone β-Promoter ActivitySemantic proximity Read ↗

p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-β Subunit GeneSemantic proximity Read ↗

Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.