Article
Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK.
The international journal of biochemistry & cell biology - 1 Jan 2007
Nicoll W S, Botha M, McNamara C, Schlange M, Pesce E-R, Boshoff A, Ludewig M H, Zimmermann R, Cheetham M E, Chapple J P, Blatch G L
Abstract excerpt
Both prokaryotic and eukaryotic cells contain multiple heat shock protein 40 (Hsp40) and heat shock protein 70 (Hsp70) proteins, which cooperate as molecular chaperones to ensure fidelity at all stages of protein biogenesis. The Hsp40 signature domain, the J-domain, is required for binding of an Hsp40 to a partner Hsp70, and may also play a role in the specificity of the association. Through the creation of...
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