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Article

A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli.

PLoS genetics - 1 Jan 2012

Perrody Elsa, Cirinesi Anne-Marie, Desplats Carine, Keppel France, Schwager Françoise, Tranier Samuel, Georgopoulos Costa, Genevaux Pierre

Abstract excerpt

The universally conserved J-domain proteins (JDPs) are obligate cochaperone partners of the Hsp70 (DnaK) chaperone. They stimulate Hsp70's ATPase activity, facilitate substrate delivery, and confer specific cellular localization to Hsp70. In this work, we have identified and characterized the first functional JDP protein encoded by a bacteriophage. Specifically, we show that the ORFan gene 057w of the T4-related...

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Identifiers

PMID: 23133404
DOI: 10.1371/journal.pgen.1003037
PMCID: PMC3486835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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