Article
Maintenance of immunological memory: a role for CD5+ B cells?
Immunology today - 1 Dec 1991
UytdeHaag F, van der Heijden R, Osterhaus A
Abstract excerpt
How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrog...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Antigens, CD
- B-Lymphocyte Subsets
- CD5 Antigens
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Hematopoietic Stem Cells
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunologic Memory
- Mice
- Models, Biological
- Mutation
- Plasma Cells
- Receptors, Antigen, B-Cell