Article
Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2007
Michou Laëtitia, Lasbleiz Sandra, Rat Anne-Christine, Migliorini Paola, Balsa Alejandro, Westhovens René, Barrera Pilar, Alves Helena, Pierlot Céline, Glikmans Elodie, Garnier Sophie, Dausset Jean, Vaz Carlos, Fernandes Manuela, Petit-Teixeira Elisabeth, Lemaire Isabelle, Pascual-Salcedo Dora, Bombardieri Stefano, Dequeker Jan, Radstake Timothy R, Van Riel Piet, van de Putte Leo, Lopes-Vaz Antonio, Prum Bernard, Bardin Thomas, Dieudé Philippe, Cornélis François
Abstract excerpt
The tyrosine phosphatase PTPN22 allele 1858T has been associated with rheumatoid arthritis (RA) and other autoimmune diseases. RA is the most frequent of those multifactorial diseases. The RA association was usually restricted to serum rheumatoid factor positive disease (RF+). No interaction was shown with HLA-DRB1, the first RA gene. Many case-control studies replicated the RA association, showing an allele...
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