Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tricyclic antidepressants, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the S1S2 domain of AMPA receptors.

Archives of biochemistry and biophysics - 15 Feb 2007

Stoll Laura, Seguin Sandlin, Gentile Lisa

Abstract excerpt

The hypothesis that depression is caused solely by a decrease in synaptic availability of monoaminergic neurotransmitters has been questioned over the past two decades. Based on accumulating data, it seems more plausible that cross-talk exists between neurotransmitters in the CNS, including the glutamatergic system. Glutamate, the major fast excitatory neurotransmitter in the CNS, is the natural agonist for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents, Second-Generation
Share to Antidepressive Agents, Tricyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Fluoxetine

Share to Peptide Hydrolases

Share to Protein Structure, Tertiary

Share to Receptors, AMPA

Share to Selective Serotonin Reuptake Inhibitors

Source

Identifiers

PMID: 17214956
DOI: 10.1016/j.abb.2006.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Tricyclic antidepressants, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the S1S2 domain of AMPA receptors.PMID 17214956Read ↗

Selective inhibitors of the FK506-binding protein 51 by induced fit.Semantic proximity Read ↗

Understanding the molecular pharmacology of the serotonergic system: using fluoxetine as a model.Semantic proximity Read ↗

A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction.Semantic proximity Read ↗

Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons.Semantic proximity Read ↗

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read ↗

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.Semantic proximity Read ↗

Amino-acid residues involved in glutamate receptor 6 kainate receptor gating and desensitization.Semantic proximity Read ↗

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.