Article
Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers.
Cancer causes & control : CCC - 1 May 2010
Kotsopoulos Joanne, Chen Zhou, Vallis Katherine A, Poll Aletta, Ghadirian Parviz, Kennedy Greg, Ainsworth Peter, Narod Steven A
Abstract excerpt
Selenium is an important cofactor of various antioxidant enzymes and has been shown to enhance DNA repair in normal human fibroblasts. Oral selenium supplementation has also been shown to decrease the number of chromosome breaks in BRCA1 mutation carriers. Because the predisposition to cancer among BRCA1 mutation carriers may be linked to high rates of DNA damage and chromosome breakage, we evaluated the...
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