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MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development

5 Jan 2007

Abstract excerpt

BACKGROUND: Cancer/testis antigens (CTAs) are expressed in several cancers and during normal adult male germ cell differentiation. Little is known about their role in fetal development of human germ cells. METHODS: We examined expression of the CTAs MAGE-A1, GAGE and NY-ESO-1 in fetal gonads by single and double immunohistochemical staining. RESULTS: We found that GAGE was expressed in the primordial germ cells...

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PMID: 17208940
DOI: 10.1093/humrep/del494

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