Article
A hexanucleotide element directs microRNA nuclear import.
Science (New York, N.Y.) - 5 Jan 2007
Hwang Hun-Way, Wentzel Erik A, Mendell Joshua T
Abstract excerpt
MicroRNAs (miRNAs) negatively regulate partially complementary target messenger RNAs. Target selection in animals is dictated primarily by sequences at the miRNA 5' end. We demonstrated that despite their small size, specific miRNAs contain additional sequence elements that control their posttranscriptional behavior, including their subcellular localization. We showed that human miR-29b, in contrast to other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.