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Article

EGFRvIII mutation in lung cancer correlates with increased EGFR copy number.

Oncology reports - 1 Feb 2007

Sasaki Hidefumi, Kawano Osamu, Endo Katsuhiko, Yukiue Haruhiro, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

Overexpression of the epidermal growth factor receptor (EGFR) is caused by EGFR gene amplification and is sometimes associated with expression of a variant EGFR (deletion exon 2-7 or EGFRvIII). EGFRvIII mutation has oncogenic potential and is investigated as a potential therapeutic target. We genotyped the EGFRvIII mutation status in 252 surgically treated lung cancer cases. The presence or absence of EGFRvIII...

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Source

Identifiers

PMID: 17203167

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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