Article
HLA class II specificities and haplotypes in South Africa detected using polymerase chain reaction and sequence-specific oligonucleotide typing.
Tissue antigens - 1 Aug 1991
Martell R W, Arendse B, Jacobs M, Du Toit E D
Abstract excerpt
DNA sequencing of HLA class II alleles has revealed a degree of polymorphism much greater than was expected on the basis of the standard serological typing methods. Amplification of the polymorphic second exon of the class II genes using the polymerase chain reaction, followed by hybridization wi...
Topics
- Alleles
- Base Sequence
- DNA
- Epitopes
- Gene Amplification
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Molecular Sequence Data
- Oligonucleotides
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- South Africa