Article
Management of familial melanoma.
The Lancet. Oncology - 1 Jan 2007
Bishop Julia Newton, Harland Mark, Randerson-Moor Juliette, Bishop D Timothy
Abstract excerpt
Relatives of patients with melanoma are at increased risk of melanoma. We review the evidence that this risk may be attributed both to shared susceptibility genes (both high-penetrance and lower-penetrance genes) and shared environment. The most frequent high-penetrance susceptibility gene is CDKN2A, and environmental effects on the risk to gene carriers are evident in that CDKN2A penetrance is higher in...
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