Article
Circumventing the effect of product toxicity: development of a novel two-stage production process for the lantibiotic gallidermin.
Applied and environmental microbiology - 1 Mar 2007
Valsesia G, Medaglia G, Held M, Minas W, Panke S
Abstract excerpt
Lantibiotics such as gallidermin are lanthionine-containing polypeptide antibiotics produced by gram-positive bacteria that might become relevant for the treatment of various infectious diseases. So far, self-toxicity has prevented the isolation of efficient overproducing strains, thus hampering their thorough investigation and preventing their exploitation in fields other than the food area. We wanted to...
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