Article
HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells.
Biochemical and biophysical research communications - 16 Feb 2007
Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke
Abstract excerpt
Sucrase-isomaltase (SI) gene expression is negatively regulated by glucose, but its molecular mechanism is not completely clear. The purpose of this study is to investigate whether HNF-1alpha and HNF-1beta contribute to glucose regulation of SI gene expression. To explore this question, we examined the association of gene expressions between SI and HNF-1alpha and HNF-1beta in Caco-2 cells cultured in medium...
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