Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenotype and growth morphology.

Abstract excerpt

Diverse histological types of lung cancer express neuroendocrine (NE) markers. We studied the expression and alternative splicing forms of the neural cell adhesion molecule (NCAM) NKH-1, a member of the immunoglobulin superfamily, in 56 lung cancer cell lines representing all histological types. We found a strong correlation between expression of NCAM with both NE phenotype and lack of substrate adhesion in...

Topics

• Antigens, Differentiation
• Base Sequence
• Blotting, Northern
• CD57 Antigens
• Cell Adhesion Molecules, Neuronal
• Humans
• Lung Neoplasms
• Molecular Sequence Data
• Neurosecretory Systems
• Phenotype