Article
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one - 20 Dec 2006
Leppänen Pia, Kholová Ivana, Mähönen Anssi J, Airenne Kari, Koota Suvi, Mansukoski Hannu, Närväinen Johanna, Wirzenius Maria, Alhonen Leena, Jänne Juhani, Alitalo Kari, Ylä-Herttuala Seppo
Abstract excerpt
We have generated a transgenic mouse where hVEGF-A(165) expression has been silenced with loxP-STOP fragment, and we used this model to study the effects of hVEGF-A(165) over-expression in mice after systemic adenovirus mediated Cre-gene transfer. Unlike previous conventional transgenic models, this model leads to the expression of hVEGF-A(165) in only a low number of cells in the target tissues in adult mice....
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