Article
HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.
Annals of the New York Academy of Sciences - 1 Nov 2006
Tromp Gerard, Ogata Toru, Gregoire Lucie, Goddard Katrina A B, Skunca Magdalena, Lancaster Wayne D, Parrado Antonio R, Lu Qing, Shibamura Hidenori, Sakalihasan Natzi, Limet Raymond, Mackean Gerald L, Arthur Claudette, Sueda Taijiro, Kuivaniemi Helena
Abstract excerpt
Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls. We observed an association with the...
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