Article
mRNA expression and RNA editing (2451 C-to-U) of IL-12 receptor beta2 in adult atopic patients.
Journal of Korean medical science - 1 Dec 2006
Kim Eun Jin, Lee Won Mok, Ha Jung Sook, Ryoo Nam Hee, Jeon Dong Suk, Kim Jae Ryong
Abstract excerpt
Interleukin (IL)-12 activates T helper (Th) 1 cells to produce interferon (IFN)-gamma which inhibits atopic inflammation. IL-12 acts through interaction with its receptor, especially beta(2) subunit. In several studies, the low production of IFN-gamma in peripheral mononuclear cells of atopic patients on response to IL-12 stimulation has been reported. Therefore we investigated the IL-12 receptor beta(2) (IL-12R...
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