Characterization of nevirapine (NVP) resistance mutations and HIV type 1 subtype in women from Abidjan (Côte d'Ivoire) after NVP single-dose prophylaxis of HIV type 1 mother-to-child transmission.

doi:10.1089/aid.2005.21.1031

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Characterization of nevirapine (NVP) resistance mutations and HIV type 1 subtype in women from Abidjan (Côte d'Ivoire) after NVP single-dose prophylaxis of HIV type 1 mother-to-child transmission.

AIDS research and human retroviruses - 1 Dec 2005

Toni Thomas D'Aquin, Masquelier Bernard, Lazaro Estibaliz, Dore-Mbami Mireille, Ba-Gomis Franck-Olivier, Téa-Diop Yacine, Kouakou Kouadio, Diby Joseph, Sia Evelyne, Soppi Sylvie, Essien Samuel, Schrive Marie-Hélène, Pinson Patricia, Chenal Henri, Fleury Hervé J

Abstract excerpt

Nevirapine (NVP) single dose is widely used in developing countries to prevent HIV-1 mother-to-child transmission. However, this regimen selects key drug resistance mutations that can impair further HAART efficacy. We studied the HIV-1 reverse transcriptase genotype from 29 Ivoirian women 1 month after an NVP single-dose prophylaxis. NVP resistance mutations were observed in six (20.7%) women. The majority of the...

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PMID: 16379606
DOI: 10.1089/aid.2005.21.1031

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