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Article

Design Strategies of Novel NNRTIs to Overcome Drug Resistance

2 Sept 2009

Abstract excerpt

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are very potent and most promising anti-AIDS drugs that specifically inhibit HIV-1 reverse transcriptase (RT). However, to a great extent, the efficacy of NNRTI drugs is impaired by rapid emergence of drug-resistance mutations. Fortunately, detailed analysis of a wide range of crystal structures of HIV-1 RT/NNRTI complexes together with data on drug...

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PMID: 19747133
DOI: 10.2174/092986709789178019

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