Article
Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.
Journal of psychiatric research - 1 Jan 2008
Laurin Nancy, Ickowicz Abel, Pathare Tejaswee, Malone Molly, Tannock Rosemary, Schachar Russell, Kennedy James L, Barr Cathy L
Abstract excerpt
The dopamine system plays an important role in the regulation of attention and motor behavior, subsequently, several dopamine-related genes have been associated with Attention Deficit/Hyperactivity Disorder (ADHD). Among them are the dopamine receptors D1 and D5 that mediate adenylyl cyclase activation through coupling with G(s)-like proteins. We thus hypothesized that the G(s)-like subunit Galpha(olf), expressed...
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