Article
Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Turic D, Langley K, Kirov G, Owen M J, Thapar A, O'Donovan M C
Abstract excerpt
We have followed up the extensive replicated evidence that the dopamine DRD4 receptor is involved in the aetiology of ADHD by undertaking direct analysis of genes encoding other proteins in this effector system. We prioritised the genes encoding G protein alpha subunits G alpha(T2), G alpha(o), G alpha(Z) as these have been shown to transduce the effects of ligand binding at DRD4. We screened the exons of all...
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