Article
Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population.
International journal of obesity (2005) - 1 Jun 2007
Gazzerro P, Caruso M G, Notarnicola M, Misciagna G, Guerra V, Laezza C, Bifulco M
Abstract excerpt
CONTEXT: Endocannabinoids control food intake via both central and peripheral mechanisms, and cannabinoid type-1 receptor (CB1) modulates lipogenesis in primary adipocyte cell cultures and in animal models of obesity. OBJECTIVES: We aimed to evaluate, at the population level, the frequency of a genetic polymorphism of CB1 and to study its correlation with body mass index. DESIGN, SETTING AND PARTICIPANTS: Healthy...
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