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Article

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.

Blood - 7 May 2015

Kühnl Andrea, Valk Peter J M, Sanders Mathijs A, Ivey Adam, Hills Robert K, Mills Ken I, Gale Rosemary E, Kaiser Martin F, Dillon Richard, Joannides Melanie, Gilkes Amanda, Haferlach Torsten, Schnittger Susanne, Duprez Estelle, Linch David C, Delwel Ruud, Löwenberg Bob, Baldus Claudia D, Solomon Ellen, Burnett Alan K, Grimwade David

Abstract excerpt

The gene CXXC5 on 5q31 is frequently deleted in acute myeloid leukemia (AML) with del(5q), suggesting that inactivation of CXXC5 might play a role in leukemogenesis. Here, we investigated the functional and prognostic implications of CXXC5 expression in AML. CXXC5 mRNA was downregulated in AML with MLL rearrangements, t(8;21) and GATA2 mutations. As a mechanism of CXXC5 inactivation, we found evidence for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Immunoenzyme Techniques

Share to Leukemia, Myeloid, Acute

Share to Real-Time Polymerase Chain Reaction

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Source

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Identifiers

PMID: 25805812
DOI: 10.1182/blood-2014-12-613703
PMCID: PMC4463809

Genes

CXXC5
GATA2
EFS
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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