Outer membrane vesicles of the VA‐MENGOC‐BC® vaccine against serogroup B <b><i>of Neisseria meningitidis</i></b>: Analysis of protein components by two‐dimensional gel electrophoresis and mass spectrometry

Abstract excerpt

Neisseria meningitidis is a Gram-negative bacterium responsible for significant mortality worldwide. While effective polysaccharides-based vaccines exist against serogroups A, C, W135, and Y, no similar vaccine is suitable for children under 4 years against disease caused by serogroup B strains. Therefore, major vaccine efforts against this serogroup are based on outer membrane vesicles (OMVs), containing major...

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