Article
Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome.
Experimental hematology - 1 Dec 2006
Holmes Denise K, Bates Nicola, Murray Mary, Ladusans E J, Morabito Antonino, Bolton-Maggs Paula H B, Johnston Tracey A, Walkenshaw Steve, Wynn Robert F, Bellantuono Ilaria
Abstract excerpt
OBJECTIVES: There is an increased risk of myeloid malignancy in individuals with Down's syndrome (DS), which is associated with a mutation in exon 2 of the transcription factor GATA-1. It is recognized that there is accelerated telomere shortening in blood cells of children with DS similar to that in conditions such as Fanconi anemia and dyskeratosis congenita. The latter conditions are associated with stem cell...
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