Article
SNPs (single nucleotide polymorphisms) detection based on the formation of cholic-acid binding DNA aptamer.
Nucleic acids symposium series (2004) - 1 Jan 2005
Kato Teru, Yuki Atsuko, Yano Kazuyoshi, Arikawa Yoshiko, Karube Isao
Abstract excerpt
Simple and rapid methods for the detection of single nucleotide polymorphisms (SNPs) are required to analyze the genetic information. We have previously isolated DNA aptamers that bind to cholic acid by an in vitro selection method. A common feature of the sequences of the aptamers was that they included a secondary structure, a three-way junction, in which three stems were connected at the junction. It was also...
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