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Article

Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada.

Journal of the National Cancer Institute - 6 Dec 2006

Risch Harvey A, McLaughlin John R, Cole David E C, Rosen Barry, Bradley Linda, Fan Isabel, Tang James, Li Song, Zhang Shiyu, Shaw Patricia A, Narod Steven A

Abstract excerpt

BACKGROUND: BRCA1 and BRCA2 mutations in general populations and in various types of cancers have not been well characterized. We investigated the presence of these mutations in unselected patients with newly diagnosed incident ovarian cancer in Ontario, Canada, with respect to cancers reported among their relatives. METHODS: A population series of 1171 unselected patients with incident ovarian cancer diagnosed...

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Source

Identifiers

PMID: 17148771
DOI: 10.1093/jnci/djj465

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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