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Article

The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant.

The Journal of biological chemistry - 23 Feb 2007

Nam Young-Jae, Mani Kartik, Wu Lily, Peng Chang-Fu, Calvert John W, Foo Roger S-Y, Krishnamurthy Barath, Miao Wenfeng, Ashton Anthony W, Lefer David J, Kitsis Richard N

Abstract excerpt

Efficient induction of apoptosis requires not only the activation of death-promoting proteins but also the inactivation of inhibitors of cell death. ARC (apoptosis repressor with caspase recruitment domain) is an endogenous inhibitor of apoptosis that antagonizes both central apoptosis pathways....

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Identifiers

PMID: 17142452
DOI: 10.1074/jbc.M609186200

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17142452-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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