Article
Expression analysis of actin-related genes as an underlying mechanism for mood disorders.
Biochemical and biophysical research communications - 19 Jan 2007
Nakatani Noriaki, Ohnishi Tetsuo, Iwamoto Kazuya, Watanabe Akiko, Iwayama Yoshimi, Yamashita Shunji, Ishitsuka Yuichi, Moriyama Kenji, Nakajima Mizuho, Tatebayashi Yoshitaka, Akiyama Haruhiko, Higuchi Teruhiko, Kato Tadafumi, Yoshikawa Takeo
Abstract excerpt
In this study, we explored the newly postulated 'disturbed cytoskeletal' theory of mood disorders. Firstly, we identified Cap1, a gene for important mediator of actin turnover, as a cogent quantitative trait gene for depressive trait of mice by combining the results of our prior genetic and current genome-wide expression analyses. Then we rigorously examined 'core' actin-related gene expression in the frontal...
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