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Article

Inherited risk factors for venous thromboembolism.

Nature reviews. Cardiology - 1 Mar 2014

Martinelli Ida, De Stefano Valerio, Mannucci Pier M

Abstract excerpt

Venous thromboembolism (VTE) has important heritable components. In the past 20 years, knowledge in this field has greatly increased with the identification of a number of gene variants causing hypercoagulability. The two main mechanisms are loss-of-function of anticoagulant proteins and gain-of-function of procoagulants, the latter owing to increased synthesis or impaired downregulation of a normal protein or,...

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PMID: 24419261
DOI: 10.1038/nrcardio.2013.211

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