Article
Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome.
Blood - 15 Mar 2007
Bodar Evelien J, van der Hilst Jeroen C H, van Heerde Waander, van der Meer Jos W M, Drenth Joost P H, Simon Anna
Abstract excerpt
Hereditary periodic fever syndromes are characterized by incapacitating attacks of fever and generalized inflammation. While the mutated genes for the major syndromes in this group are known, the pathogenesis remains unclear. The aim of this study was to investigate apoptosis in patients with periodic fever as a possible pathogenic factor. We measured anisomycin-induced apoptosis with annexin-V flow cytometry and...
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