Engineered blood and lymphatic capillaries in 3‐D VEGF‐fibrin‐collagen matrices with interstitial flow

Abstract excerpt

In vitro endothelial cell organization into capillaries is a long standing challenge of tissue engineering. We recently showed the utility of low level interstitial flow in guiding the organization of endothelial cells through a 3-D fibrin matrix-containing covalently bound vascular endothelial growth factor (VEGF). Here this synergistic phenomenon was extended to explore the effects of matrix composition on in...

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