Article
Genetic determinants of type 1 diabetes across populations.
Annals of the New York Academy of Sciences - 1 Oct 2006
Jahromi Mohamed M, Eisenbarth George S
Abstract excerpt
T1D results from autoimmune-mediated destruction of the pancreatic beta cells, a process that is conditioned by multiple genes and environmental factors. The main genetic determinants map to the major histocompatibility complex (MHC), and in particular DR and DQ, although, genes outside the MHC contribute, including the insulin gene, PTPN22, and CTLA-4. There are remarkable differences in genetic susceptibility...
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