Article
Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2006
Järvinen Elina, Salazar-Ciudad Isaac, Birchmeier Walter, Taketo Makoto M, Jernvall Jukka, Thesleff Irma
Abstract excerpt
The single replacement from milk teeth to permanent teeth makes mammalian teeth different from teeth of most nonmammalian vertebrates and other epithelial organs such as hair and feathers, whose continuous replacement has been linked to Wnt signaling. Here we show that mouse tooth buds expressing stabilized beta-catenin in epithelium give rise to dozens of teeth. The molar crowns, however, are typically...
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