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Article

Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of <i>XIAP</i> gene promoter through Sp1 sites

1 Nov 2006

Abstract excerpt

Mithramycin A is a DNA-binding antitumor agent, which has been clinically used in the therapies of several types of cancer and Paget's disease. In this study, we investigated the combined effect of mithramycin A and tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) on apoptosis of cancer cells. In Caki renal cancer cells, which are resistant to TRAIL, cotreatment with subtoxic doses of...

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PMID: 17121920
DOI: 10.1158/1535-7163.mct-06-0426

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Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of <i>XIAP</i> gene promoter through Sp1 sitesPMID 17121920Read ↗

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