Article
Polymorphisms in the thymidylate synthase promoter and the DNA repair genes XRCC1 and XPD in a Brazilian population.
Environmental and molecular mutagenesis - 1 Dec 2006
Canalle Renata, da Silva S Andrade Vanessa, Scrideli Carlos A, de Paula Queiroz Rosane G, Tone Luiz G
Abstract excerpt
Polymorphisms in genes responsible for maintaining genomic integrity are potential modifiers of disease risk. Since considerable interindividual and interethnic variation in DNA repair capacity has been associated with polymorphic alleles, we evaluated the frequency of the 2R/3R variants in the TS promoter, Arg194Trp and Arg399Gln in the XRCC1 gene, and Asp312Asn and Lys751Gln in the XPD gene in 364 healthy...
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