Article
Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum.
The Journal of infectious diseases - 15 Dec 2006
Marra Christina M, Colina April P, Godornes Charmie, Tantalo Lauren C, Puray Maritza, Centurion-Lara Arturo, Lukehart Sheila A
Abstract excerpt
To determine whether the 23S rRNA mutation that confers macrolide resistance is present in >1 Treponema pallidum strain, 58 isolates collected between 2001 and 2005 were screened for this mutation and for an unrelated sequence that distinguishes between strains. The odds of identifying a macrolide-resistant strain increased over time (P=.006). In subjects who had received macrolides in the previous year, the...
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