Article
New advances in the genetics of pheochromocytoma and paraganglioma syndromes.
Annals of the New York Academy of Sciences - 1 Aug 2006
Gimenez-Roqueplo Anne-Paule
Abstract excerpt
The discovery of the SDH genes in 2000/2001 dramatically changed the genetics of pheochromocytoma (PHEO) and paraganglioma (PGL). Five years on, it is widely accepted that all patients with PHEO/PGL, whatever their age, should undergo genetic testing, because 25-30% of PHEOs are caused by a germline mutation in one of the five PHEO susceptibility genes. However, genetic testing should be targeted according to...
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